Behavior of the Right Ventricle Following Acute Constriction of the Pulmonary Artery

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Abstract
In 15 anesthetized dogs, constriction of the lumen of the pulmonary artery by less than 50 per cent produced no significant change in intraventricular pressure or cardiac output. Additional constriction caused a progressive increase of the right ventricular pressure; up to a pressure of 62.3±3./min. Hg, there was no change in cardiac output. With higher right ventricular systolic pressure there was a reduction in cardiac output, gradual decrease in systolic pressure but increase in diastolic pressure of both ventricles, and ultimately dilatation of the heart and ventricular arrest or fibrillation.