INHIBITORY EFFECT OF CAPSELLA-BURSA-PASTORIS EXTRACT ON GROWTH OF EHRLICH SOLID TUMOR IN MICE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 36  (6) , 1900-1903
Abstract
The treatment of ICR mice with i.p. injections (0.14 g/kg per day) of the extract of C. bursa-pastoris herb (Cruciferae) caused 50-80% inhibition of the solid growth of Ehrlich tumor cells that were inoculated into the s.c. tissue of the animals. The tumor lumps in the treated mice showed multifocal necroses and the infiltration of host fibrous tissue cells. Experiments were also performed to isolate and identify the active component for antitumor action, and an acidic substance was isolated in crystalline form from the herb extract. This acidic substance was identified as fumaric acid and was effective in inhibiting the growth of Ehrlich solid tumor at a dose of 10 mg/kg per day. The LD50 (i.p.) of this acid was 266 mg/kg.

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