A triple helix model for the structure of chromatin fiber
Open Access
- 25 February 1985
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 181 (2) , 357-361
- https://doi.org/10.1016/0014-5793(85)80292-1
Abstract
A model of chromatin fiber structure is presented in which a repeating unit of a trinucleosome forms a 3‐dimensional zigzag. Twisting and compression of the zigzag result in a triple helix structure. The model is built mainly on the flow linear dichroism data showing that (a) nucleosomal disc faces are tilted relative to the fiber axis, (b) the orientation of nucleosomes does not change upon folding and unfolding of chromatin, and (c) the orientation of nucleosomes is maintained by the globular domain of histone HI.Keywords
This publication has 23 references indexed in Scilit:
- The higher-order structure of chromatin: evidence for a helical ribbon arrangement.The Journal of cell biology, 1984
- Orientation of nucleosomes and linker DNA in calf thymus chromatin determined by photochemical dichroismNature, 1984
- Higher order structure of chromatin: Orientation of nucleosomes within the 30 nm chromatin solenoid is independent of species and spacer lengthCell, 1983
- Possible nucleosome arrangements in the higher-order structure of chromatinInternational Journal of Biological Macromolecules, 1983
- Structure of chromatin and the linking number of DNA.Proceedings of the National Academy of Sciences, 1981
- Orientation of the nucleosome within the higher order structure of chromatinCell, 1980
- Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin.The Journal of cell biology, 1979
- Higher‐Order Structures of Chromatin in SolutionEuropean Journal of Biochemistry, 1979
- Involvement of histone H1 in the organization of the chromosome fiber.Proceedings of the National Academy of Sciences, 1977
- Solenoidal model for superstructure in chromatin.Proceedings of the National Academy of Sciences, 1976