INDUCTION OF UROGENITAL ANOMALIES AND SOME TUMORS IN PROGENY OF MICE RECEIVING DIETHYLSTILBESTROL DURING PREGNANCY

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (4) , 1099-1104
Abstract
Pregnant mice given a single dose (10 .mu.g/g body weight) of diethylstilbestrol (DES) on days 7-19, which correspond to the 1st-5th lunar months in humans, using a 14C-labeled compound, confirmed easy placental penetration by DES. Treatment with DES on days 15-19 resulted in the induction of persistent uorgenital sinus (15.8-92.5%) and hypertrophy of the portio vaginalis (11.8-73.3%) in female offspring, and treatment on days 17 and 19 resulted in the induction of undescended testes and their hypogenesis (70.4-73.3%) in male offspring, although treatment with DES at other stages of pregnancy and after birth did not cause these alterations. The incidence of various tumors (lung adenoma, granulosa cell tumor, etc.) increased significantly (31.0-37.9%) when DES was given on days 15 and 17, which correspond to the stage sensitive to other carcinogens. Adenosis and adenocarcinoma of the vagina were not observed in the offspring.

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