TYPES OF MUCOSAL METAPLASIA IN RELATION TO THE HISTOGENESIS OF GASTRIC-CARCINOMA

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 108  (3) , 220-224
Abstract
Surgically resected stomachs (139) and stomachs obtained at necropsy (16) in China were studied histochemically to evaluate the types and distribution of mucosal metaplasia in relation to benign and malignant disease. Three classes of mucin were distinguished: small intestinal (N-acylated sialomucin); colonic (sulfated and O-acylated sialomucin); and gastric (neutral mucin). Small-intestinal metaplasmia (SIM) occurred in 95% of instances of atrophic gastritis, 36% of cases of superficial gastritis, 60% of cases of gastric ulcers, and 39% of cases of duodenal ulcers. Colonic metaplasia (CIM) was less common and was found in only 11% of benign lesions. It was located in the antrum, particularly on the lesser curvature. Mucin was present in 66 of 84 carcinomas. The stomach tumors fell into 3 histochemical groups: colonic (acid mucin), 32; gastric (neutral mucin), 19; and mixed (acidic and neutral), 15. In 94% (30/32) of colonic gastric carcinoma, CIM was present. Thus, CIM is related to development of colonic gastric carcinoma, whereas SIM is a nonspecific reaction to mucosal damage.