Aged BALB/c Mice as a Model for Increased Severity of Severe Acute Respiratory Syndrome in Elderly Humans
Open Access
- 1 May 2005
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 79 (9) , 5833-5838
- https://doi.org/10.1128/jvi.79.9.5833-5838.2005
Abstract
Advanced age has repeatedly been identified as an independent correlate of adverse outcome and a predictor of mortality in cases of severe acute respiratory syndrome (SARS). SARS-associated mortality may exceed 50% for persons aged 60 years or older. Heightened susceptibility of the elderly to severe SARS and the ability of SARS coronavirus to replicate in mice led us to examine whether aged mice might be susceptible to disease. We report here that viral replication in aged mice was associated with clinical illness and pneumonia, demonstrating an age-related susceptibility to SARS disease in animals that parallels the human experience.Keywords
This publication has 35 references indexed in Scilit:
- Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in TaiwanHuman Pathology, 2005
- Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeysVirology, 2004
- Clinical Features and Short-term Outcomes of 144 Patients With SARS in the Greater Toronto AreaJAMA, 2003
- Lung pathology of fatal severe acute respiratory syndromeThe Lancet, 2003
- Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective studyThe Lancet, 2003
- Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong KongThe Lancet, 2003
- Cutting Edge: Impaired Toll-Like Receptor Expression and Function in AgingThe Journal of Immunology, 2002
- An Aged Mouse Model for RSV Infection and Diminished CD8+ CTL ResponsesExperimental Biology and Medicine, 2002
- Immunosenescence and infectious diseasesMicrobes and Infection, 2001
- Aging and proinflammatory cytokinesCurrent Opinion in Hematology, 2001