The pathophysiology and clinical characteristics of severe hypophosphatemia

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Abstract
A selective review of available literature on hypophosphatemia published over the past 50 yr and a limited number of observations on patients and experimental animals are given. An attempt is made to examine mechanisms by which hypophosphatemia and P depletion probably occur, outline the resulting clinical disturbances and suggest a plan of treatment. Severe hypophosphatemia is most often observed in chronic alcoholics, patients recovering from diabetic ketoacidosis, and those being therapeutically refed after severe weight loss.