In vitro antimicrobial activity of imipenem in combination with vancomycin or teicoplanin againstStaphylococcus aureus andStaphylococcus epidermidis

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Abstract
The interaction between imipenem and two glycopeptides against staphylococci was examined for potential synergy. Imipenem in combination with vancomycin or teicoplanin exerted a synergistic or additive effect against a majority ofStaphylococcus aureus andStaphylococcus epidermidis isolates tested by the checkerboard method. Synergistic inhibitory effects were frequently accompanied by synergistic bactericidal effects. For a proportion of bacterial isolates of both species, the demonstration of synergy by the checkerboard method was confirmed by time-kill studies using antibiotic combinations at the MICs or at achievable serum antibiotic levels. Only with a single isolate ofStaphylococcus epidermidis was antagonism with either antibiotic combination recorded.

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