Comparative Photodynamic Therapy of B16 Pigmented Melanoma with Different Generations of Sensitizers

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Abstract
In order to apply photodynamic therapy to pigmented neoplasms, comparative photosensitizing studies of B 16 pigmented melanoma in C 57 B 1/6 mice were carried out with haematoporphyrin derivative (HpD), zinc(II) phthalocyanine ( ZnPc ), zinc(II) naphthalocyanine ( ZnNc ) and tetrabenzamido-substituted zinc(II) naphthalocyanine ( ZnNcA ). By injection of the optimal drug concentration and application of the optimal dose of light irradiation (the emission of the laser dye corresponding to the λmax value of the respective sensitizer) a phototherapeutic effect was observed only after photosensitization with the longest-wavelength-absorbing sensitizer, namely ZnNcA . It is supposed that the detected, through different assessment criteria, promising phototherapeutic effect after ZnNcA photosensitization of B 16 pigmented melanoma in mice is due to suitable structural, photophysical and photochemical properties of this sensitizer, but not due to a hyperthermic effect. This assumption is supported by the results obtained after irradiation of B 16 pigmented melanoma-bearing mice with the same fluence rate and fluence but without the sensitizer. In this case the tumour temperature did not increase by more than 35 °C and no changes in the mean tumour diameter or in the malignant subcellular components were detected.

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