Understanding HIV-1 Drug Resistance
- 1 April 2004
- journal article
- review article
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 26 (2) , 116-121
- https://doi.org/10.1097/00007691-200404000-00005
Abstract
Infection with drug-resistant HIV-1 may result from the acquisition of mutant strains or from their selection within the individual; either can compromise the efficacy of antiretroviral therapy (ART). Drug-resistance testing is recommended to assist in the choice of ART. Herein, factors that contribute to the selection of drug-resistant virus and details important to the interpretation of the genotypic and phenotypic susceptibility test results are reviewed.Keywords
This publication has 78 references indexed in Scilit:
- Virtual Inhibitory Quotient Predicts Response to Ritonavir Boosting of Indinavir-Based Therapy in Human Immunodeficiency Virus-Infected Patients with Ongoing ViremiaAntimicrobial Agents and Chemotherapy, 2002
- Rapid and Sensitive Oligonucleotide Ligation Assay for Detection of Mutations in Human Immunodeficiency Virus Type 1 Associated with High-Level Resistance to Protease InhibitorsJournal of Clinical Microbiology, 2002
- Vertical Transmission of Multidrug‐Resistant Human Immunodeficiency Virus Type 1 (HIV‐1) and Continued Evolution of Drug Resistance in an HIV‐1–Infected InfantThe Journal of Infectious Diseases, 2001
- Zidovudine Genotypic Resistance in HIV-1–Infected Newborns in the French Perinatal CohortJAIDS Journal of Acquired Immune Deficiency Syndromes, 2001
- A Novel Recombinant Marker Virus Assay for Comparing the Relative Fitness of HIV-1 Reverse Transcriptase VariantsJAIDS Journal of Acquired Immune Deficiency Syndromes, 2001
- Combination Nucleoside Analog Reverse Transcriptase Inhibitor(s) Plus Nevirapine, Nelfinavir, or Ritonavir in Stable Antiretroviral Therapy-Experienced HIV-Infected Children: Week 24 Results of a Randomized Controlled Trial - PACTG 377AIDS Research and Human Retroviruses, 2000
- Combination Therapy with Efavirenz, Nelfinavir, and Nucleoside Reverse-Transcriptase Inhibitors in Children Infected with Human Immunodeficiency Virus Type 1New England Journal of Medicine, 1999
- Efavirenz plus Zidovudine and Lamivudine, Efavirenz plus Indinavir, and Indinavir plus Zidovudine and Lamivudine in the Treatment of HIV-1 Infection in AdultsNew England Journal of Medicine, 1999
- Codon 215 Mutations in Human Immunodeficiency Virus–Infected Pregnant WomenThe Journal of Infectious Diseases, 1999
- Effects of Zidovudine Use During Pregnancy on Resistance and Vertical Transmission of Human Immunodeficiency Virus Type 1Clinical Infectious Diseases, 1995