Familial elevations of total and free thyroxine in healthy, euthyroid subjects without detectable binding protein abnormalities
- 1 June 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 100 (2) , 224-230
- https://doi.org/10.1530/acta.0.1000224
Abstract
: Elevations of serum thyroxine without thyrotoxicosis or binding protein abnormalities have been documented in 8 of 13 family members, representing 4 generations. This syndrome appears to represent an elevated threshold for the amount of free thyroxine substrate required to maintain adequate T3 production form the peripheral monodeiodination of T4. It reiterates the need for a prudent re-evaluation of all clinically euthyroid patients with elevated serum thyroxine concentrations before concluding that they are indeed thyrotoxic.This publication has 15 references indexed in Scilit:
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