Prevention of Peroxynitrite-Dependent Tyrosine Nitration and Inactivation of α1-Antiproteinase by Antibiotics
- 1 January 1997
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research
- Vol. 26 (1) , 49-56
- https://doi.org/10.3109/10715769709097783
Abstract
Peroxynitrite, formed by reaction of superoxide and nitric oxide, appears to be an important tissue damaging species generated at sites of inflammation. In this paper, we compare the abilities of several antibiotics to protect against peroxynitrite-dependent inactivation of α1-antiproteinase, and to inhibit tyrosine nitration by peroxynitrite, in vitro. Tetracycline, minocycline, doxycycline, rifamycin and rifampicin were highly-protective in both assay systems, whereas several other antibiotics tested were not. The possibility that antibiotics could affect tissue injury at sites of inflammation by scavenging peroxynitrite is discussed.Keywords
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