Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase
Open Access
- 2 August 2004
- journal article
- fj express-summary
- Published by Wiley in The FASEB Journal
- Vol. 18 (13) , 1618-1620
- https://doi.org/10.1096/fj.04-1945fje
Abstract
The contributing role of environmental factors to the development of Parkinson’s disease has become increasingly evident. We report that mesencephalic neuron-glia cultures treated with diesel exhaust...Keywords
This publication has 40 references indexed in Scilit:
- Critical role of microglial NADPH oxidase‐derived free radicals in the in vitro MPTP model of Parkinson's diseaseThe FASEB Journal, 2003
- Reactive oxygen species in pulmonary inflammation by ambient particulatesFree Radical Biology & Medicine, 2003
- Critical Role for Microglial NADPH Oxidase in Rotenone-Induced Degeneration of Dopaminergic NeuronsJournal of Neuroscience, 2003
- Selective microglial activation in the rat rotenone model of Parkinson's diseaseNeuroscience Letters, 2003
- Synergistic Dopaminergic Neurotoxicity of the Pesticide Rotenone and Inflammogen Lipopolysaccharide: Relevance to the Etiology of Parkinson's DiseaseJournal of Neuroscience, 2003
- Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosisToxicology and Applied Pharmacology, 2003
- THE DUAL EFFECT OF THE PARTICULATE AND ORGANIC COMPONENTS OF DIESEL EXHAUST PARTICLES ON THE ALTERATION OF PULMONARY IMMUNE/INFLAMMATORY RESPONSES AND METABOLIC ENZYMESJournal of Environmental Science and Health, Part C, 2002
- Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats.Environmental Health Perspectives, 2001
- MPP+ Injection into Rat Substantia Nigra Causes Secondary Glial Activation but Not Cell Death in the Ipsilateral StriatumNeurobiology of Disease, 2000
- Diesel Exhaust Particles Induced Release of Interleukin 6 and 8 by (Primed) Human Bronchial Epithelial Cells (Beas 2b) In VitroExperimental Lung Research, 1998