ISOCITRATE UPTAKE AND CITRATE PRODUCTION BY RAT VENTRAL PROSTATE FRAGMENTS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 16  (1) , 44-47
Abstract
Prostatic aconitase was investigated utilizing fragments of rat ventral prostate. The rate of citrate formation from isocitrate was used as an index of aconitase activity. Inhibition of citrate formation from isocitrate by fluorocitrate indicated that aconitase activity was being measured. Whereas both kidney and prostate formed citrate from isocitrate, the aconitase activity of prostate was independent of both medium isocitrate and citrate concentration. The aconitase activity of prostate seemed to favor citrate formation to a much greater degree than kidney. The aconitase catalyzed conversion of citrate to isocitrate was limited in prostate and the deficient citrate oxidation observed in prostate was the result of a unique aconitase activity.

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