Structure and function of heparin-binding EGF-like growth factor HB-EGF
- 1 January 1998
- journal article
- review article
- Published by IMR Press in Frontiers in Bioscience-Landmark
- Vol. 3 (4) , d288-299
- https://doi.org/10.2741/a241
Abstract
Heparin-binding EGF-like growth factor (HB-EGF) is a 22 kDa, O-glycosylated protein that is mitogenic for fibroblasts, smooth muscle cells (SMC) and epithelial cells. This review describes the primary structure of HB-EGF, as well as its processing. The structure of the mouse and human HB-EGF genes is also discussed. Finally, this review summarizes HB-EGF expression patterns, receptor-mediated signaling, and role in several important biological systems.Keywords
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