Factors Associated With Weight Loss After Gastric Bypass

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Abstract
Roux-en-Y gastric bypass (GBP) is the most common bariatric operation used in North America.1-3 When performed in high-volume centers and with a low rate of complications, GBP provides sustained and meaningful weight loss,4-6 significant improvement in quality of life,7,8 improvement or resolution of obesity-associated comorbidities,1,9 and extended life span.10,11 Gastric bypass achieves weight reduction mainly through restriction of intake imposed by a small gastric pouch, but also by preventing contact between the food bolus and most of the stomach, duodenum, and first portion of the jejunum while delivering it in an alimentary limb of variable length in a Roux-en-Y fashion.5,12 However, 5% to 15% of patients do not lose weight successfully, despite perceived precise surgical technique and regular follow-up.6,13