Release by tubocurarine of dopamine and homovanillic acid from the superfused caudate nucleus

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Abstract
The release of dopamine and its metabolite homovanillic acid from the "superfused" caudate nucleus was studied in the cat. Fhiorimetric assay of the 2 compounds was carried out on 30 min. samples of artificial cerebrospinal fluid perfused through the anterior horn of one lateral ventricle. When tubocurarine 0.5 or 1 x 10"^ g/ml was added to the perfusion fluid, amounts of dopamine of the order of 0.1 ng/min, and very much larger quantities of homovanillic acid (up to 8 ng/min) appeared in the perfusing fluid. No release of dopamine was obtained under conditions when tubocurarine failed to produce any clinical signs or when gallamine was substituted for tubocurarine.