Retinal-Cell–Conditioned Medium Prevents TNF-α-Induced Apoptosis of Purified Ganglion Cells

1 August 2005

journal article
Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science

Vol. 46 (8) , 2983-2991
https://doi.org/10.1167/iovs.04-1177

Abstract

Purpose. Retinal ischemic processes occurring in glaucoma or diabetic retinopathy induce the secretion of tumor necrosis factor (TNF)-α. This cytokine was reported to be either toxic to or protective of retinal ganglion cells (RGCs). In the present study, its effect on RGCs was analyzed in different culture conditions.

Keywords

APOPTOSIS
DIABETIC
RETINAL
TNF
RGCS
RETINOPATHY
NECROSIS
SECRETION
ISCHEMIC

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