Depression of the Intestinal Uptake of Radio-vitamin B12 by Cholestyramine

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Abstract
Cholestyramine decreased the intestinal absorption of radio–B12 as measured by the double label hepatic uptake test in 10 consecutive normal adult volunteers, and in a patient with pernicious anemia. The mechanism of this inhibition was explored in vitro using the guinea pig intestinal mucosal homogenate assay. The in vitro studies suggested that cholestyramine decreased intrinsic factor–mediated B12 absorption probably by binding to a portion of the same binding sites on the intrinsic factor molecule which normally bind B12. This would impair the formation of the intrinsic factor–B12 complex.

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