Cellular and molecular neuroscience of alcoholism
- 1 January 1997
- journal article
- review article
- Published by American Physiological Society in Physiological Reviews
- Vol. 77 (1) , 1-20
- https://doi.org/10.1152/physrev.1997.77.1.1
Abstract
Recent advances in neuroscience have made it possible to investigate the pathophysiology of alcoholism at a cellular and molecular level. Evidence indicates that ethanol affects hormone- and neurotransmitter-activated signal transduction, leading to short-term changes in regulation of cellular functions and long-term changes in gene expression. Such changes in the brain probably underlie many of the acute and chronic neurological events in alcoholism. In addition, genetic vulnerability also plays a role in alcoholism and, perhaps, in alcoholic medical disorders.Keywords
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