Chemotaxis in : Effect of concanavalin A on chemoattractant mediated cyclic GMP accumulation and light scattering decrease
- 1 March 1978
- journal article
- Published by Wiley in Cell Biology International Reports
- Vol. 2 (2) , 163-170
- https://doi.org/10.1016/0309-1651(78)90037-1
Abstract
In cells of the cellular slime mold Dictyostelium discoideum concanavalin A (Con A), at a concentration of 100 μg per ml, inhibits folic acid and cyclic AMP induced decrease in light scattering. Con A has no effect on folic acid mediated cyclic GMP accumulation and increases cyclic AMP mediated cyclic GMP accumulation two-fold. At a lower Con A concentration, 10 μg per ml, changes in light scattering induced by folic acid are normal and cyclic AMP induces a monophasic instead of a biphasic response. The stimulatory effect of Con A on cyclic AMP mediated cyclic GMP accumulation is still observable at 10 μg Con A per ml. When cells are repeatedly stimulated with cyclic AMP, a decrease in light scattering without being accompanied by changes in cyclic GMP concentration is observed. Based on these results a model for chemotaxis is proposed.Keywords
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