Cerebral malaria in inbred mice. I. A new model and its pathology
- 31 December 1982
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 76 (3) , 410-415
- https://doi.org/10.1016/0035-9203(82)90203-6
Abstract
Plasmodium berghei ANKA was tested for its usefulness as a model for cerebral malaria in inbred mouse strains A, A2G, A/J, C57L, SJL/J and SWR. A suitable model was obtained in A or A/J strain mice. Mortality was 100% after five to eight days with brain haemorrhages occurring terminally. The histopathology is described. The model was stable after six blood passages at 5- to 7-day intervals. Chloroquine abolished the haemorrhages and no intercurrent viral or blood protozoal infections were detected.Keywords
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