Prostaglandins, Nutmeg and Diarrhea
- 10 January 1974
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 290 (2) , 110-111
- https://doi.org/10.1056/nejm197401102900221
Abstract
To the Editor: Since nutmeg might relieve diarrhea induced by prostaglandins (PGs),1 we studied ground whole nutmeg on rat isolated gastric fundus muscle (Krebs solution, 37°C, 5 per cent carbon dioxide in oxygen) and on PC synthesis by human colon. Nutmeg, 20 to 500 μg per milliliter, produced graded inhibition (20 to 100 per cent) of contraction of rat fundus strips to PGE2, acetylcholine. 5-hydroxytryptamine and histamine (four experiments). Nutmeg, 20 and 100 μg per milliliter, had little effect on the tone of the tissue, but 0.2 to 2 mg per milliliter usually tended to cause a reduction. . . .Keywords
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