Dose‐response Curve for the Ergotamine‐induced Decrease of Peripheral Systolic Blood Pressure in Man

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Abstract
Ergotamine tartrate (approximately 0.05, 0.125, 0.25 and 0.5 mg/70 kg body wt) was given i.v. to 5 volunteers in a double-blind cross-over study. For 6 h the following parameters were studied: arm, ankle and big toe systolic blood pressures. A dose-dependent but transient increase of arm systolic blood pressure was found. For changes of ankle-arm systolic gradients no dose-response curve could be established. Toe-arm systolic gradients showed a dose-dependent decrease, which at 4-6 h seems suitable for pharmacodynamic comparison of different doses or routes of administration of ergotamine tartrate.