Aluminum Triflate-Mediated Aldol Reactions. Stereoselective Synthesis of Both Diastereomers Including the α-Alkoxy-β-hydroxy-β-methyl Units.
- 1 January 1993
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1993 (11) , 855-857
- https://doi.org/10.1055/s-1993-22632
Abstract
Both diastereomers including the syn- and anti-α-alkoxy-β-hydroxy-β-methyl units are prepared from (E)- and (Z)-1-trimethylsiloxy-1-ethylthio-2-benzyloxyethene and a pyruvic acid ester, respectively, by using aluminum triflate-mediated aldol reactions. (±)-2-C-Methyl-D-erythrono-1,4-lactone and (±)-2-C-methyl-D-threono-1,4-lactone are synthesized by using these reactions.Keywords
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