Characterization and Uses of Monoclonal Antibody Derived Against DNA Binding Domain of the ETS Family of Genes
- 1 June 1992
- journal article
- research article
- Published by Mary Ann Liebert Inc in Hybridoma
- Vol. 11 (3) , 277-294
- https://doi.org/10.1089/hyb.1992.11.277
Abstract
A monoclonal antibody recognizing ets proteins from a variety of species has been developed. This antibody recognizes ets1, ets2, erg, and other related proteins. It has a high affinity for the ets1 protein. The epitope for the pan ets mAb consists of about 13 amino acids. This antibody can be used to isolate and characterize new members of ets gene family derived from a c-DNA expression library, as well as to identify other "ets motif" binding proteins.Keywords
This publication has 36 references indexed in Scilit:
- Diversity and specificity in transcriptional regulation: the benefits of heterotypic dimerizationTrends in Biochemical Sciences, 1991
- Identification of Ets- and Notch-Related Subunits in GA Binding ProteinScience, 1991
- Convergence of Ets- and Notch-Related Structural Motifs in a Heteromeric DNA Binding ComplexScience, 1991
- Nuclear targets for transcription regulation by oncogenesTrends in Genetics, 1991
- Monoclonal Antibodies Specific to Human ETS-2 Oncoprotein: Recognition of Epitopes Clustered on the B DomainHybridoma, 1990
- The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence.Genes & Development, 1990
- Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus.Genes & Development, 1990
- The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogeneCell, 1990
- Spatial and temporal patterns of E74 transcription during Drosophila developmentCell, 1990
- erg , a Human ets -Related Gene on Chromosome 21: Alternative Splicing, Polyadenylation, and TranslationScience, 1987