EFFECT OF TRAUMA ON PLASMA GLUCAGON AND INSULIN CONCENTRATIONS IN SHEEP

  • 1 January 1976
    • journal article
    • research article
    • Vol. 40  (1) , 5-8
Abstract
Portal plasma glucagon and insulin concentrations were measured before and after acute trauma (liver biopsy). The trauma was sufficient to increase glucagon concentrations and depress insulin concentrations. These changes were associated with a marked hyperglycemia. Infusion of glucagon was insufficient to prevent stress inhibition of insulin secretion. The stimulation of glucagon secretion and inhibition of insulin secretion were of about 1 h duration. Glucagon and insulin in conjunction with the nervous system may play an important role in the development of stress related hyperglycemia.