1ST MICROBIOLOGICAL APPROACH TO DACTIMICIN, A NOVEL AMINOGLYCOSIDE ANTIBIOTIC

  • 1 January 1987
    • journal article
    • research article
    • Vol. 13  (12) , 727-729
Abstract
Dactimicin (ST 900) is the first aminoglycoside antibiotic of Dactylosporangum origin. This drug shows resistance to many enzymes that destroy aminoglycosides in this first approach, the authors have pointed out the activity of dactimicin against Gram-negative rods, particularly Klebsiella Enterobacter, Serratia and Gram positive bacteria, especially methicillin susceptible and resistant staphylococci. Dactimicin showed remarkable antibacterial activity against all strains tested; however this activity was strongly influenced by the inoculum size. The bactericidal activity of dactimicin towards some Gram-positive and Gram-negative bacteria was also evaluated.

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