Anion selectivity of the chloride-transport process in dog tracheal epithelium

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Abstract
Fluxes of 82Br or 131I were measured across short-circuited dog tracheal epithelium following complete replacement of Cl- in the bathing medium by Cl- or I-. Also the bathing Cl- was partly replaced with Br-, I-, or thiocyanate; effects of these anions on 36Cl fluxes were studied. Affinity sequence for the Cl- transport process is I > Br .simeq. Cl; Br is transported, but I is not. Thiocyanate is a potent inhibitor of Cl- transport, and its effects are greater than those predicted by a simple competitive interaction with Cl- for transport sites.