Efficient and Convergent CouplingRoute for the Short-step Synthesis of Enantiopure 2α-and 2β-Alkylated 1α,25-Dihydroxy-19-norvitaminD3Analogues
- 11 June 2003
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2003 (8) , 1175-1179
- https://doi.org/10.1055/s-2003-39908
Abstract
Novel efficient synthesis of several enantio-pure 2-alkylated 1α,25-dihydroxy-19-norvitamin D3 analogues through radical introduction of 2-alkyl chain and C5-C6 position coupling using Julia-type olefination as key steps was established starting from commercially available (-)-quinic acid as a chiral pool.Keywords
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