Continuous Intraarterial Measurement of Oxygenation during Aerosolized Prostacyclin Administration in Severe Respiratory Failure

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Abstract
A recent report1 stimulated us to use aerosolized prostaglandin I2 (PGI2; also called prostacyclin or epoprostenol) to improve arterial oxygenation by producing selective pulmonary vasodilation in well-ventilated areas. PGI2 decreases microvascular pressure in the lung and reduces pulmonary fluid filtration and right-heart afterload2.