Molecular Neurobiology of Addiction
- 1 July 2001
- journal article
- review article
- Published by Wiley in The American Journal on Addictions
- Vol. 10 (3) , 201-217
- https://doi.org/10.1080/105504901750532094
Abstract
Addiction can be viewed as a form of drug‐induced neural plasticity. One of the best established molecular mechanisms of addiction is the upregulation of the cAMP second messenger pathway, which occurs in many neuronal cell types in response to chronic administration of opiates or other drugs of abuse. This upregulation and the resulting activation of the transcription factor CREB appear to mediate aspects of tolerance and dependence. In contrast, induction of another transcription factor, termed ΔFosB, exerts the opposite effect and may contribute to sensitized responses to drug exposure. Knowledge of these mechanisms could lead to more effective treatments for addictive disorders.Keywords
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