The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology
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Open Access
- 10 November 2004
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 24 (45) , 10099-10102
- https://doi.org/10.1523/jneurosci.2680-04.2004
Abstract
A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.Keywords
This publication has 26 references indexed in Scilit:
- Independent Cellular Processes for Hippocampal Memory Consolidation and ReconsolidationScience, 2004
- Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical NeuronsJournal of Neuroscience, 2004
- Early Striatal Dendrite Deficits followed by Neuron Loss with Advanced Age in the Absence of Anterograde Cortical Brain-Derived Neurotrophic FactorJournal of Neuroscience, 2004
- The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal FunctionPublished by Elsevier ,2003
- A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human BrainsNeuroImage, 2001
- Voxel-Based Morphometry—The MethodsNeuroImage, 2000
- Characterizing Stimulus–Response Functions Using Nonlinear Regressors in Parametric fMRI ExperimentsNeuroImage, 1998
- A nonparametric method for automatic correction of intensity nonuniformity in MRI dataIEEE Transactions on Medical Imaging, 1998
- AFNI: Software for Analysis and Visualization of Functional Magnetic Resonance NeuroimagesComputers and Biomedical Research, 1996
- Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampusNature, 1996