Effect of Hemoperfusion on Clearance of Gentamicin, Cephalothin, and Clindamycin from Plasma of Normal Dogs

Publisher Website
Google Scholar
Abstract
Nine normal dogs were divided into three groups of three. Group 1 was given an overdose of gentamicin; group 2, cephalothin; and group 3, clindamycin. Group 1 had hemoperfusion with Amberlite® XE-336, and groups 2 and 3 with Amberlite® XAD-4 resin adsorbents, for 6 hr with a blood flow rate of 300 mljmin. The plasma clearance and removal rates of antibiotics by the hemoperfusion columns were high. The clearance rate of gentamicin from plasma (mean ± standard deviation) ranged from 59 ± 30 to 199 ± 6 mlj min, of cephalothin from 66 ± 14 to 157 ± 8 mlj'min, and of clindamycin from 55 ± 9 to 125 ± 16 mljrnin. Of the total dose of antibiotic administered, the hemoperfusion columns removed 67% from the plasma in group 1, 41% in group 2, and 18% in group 3. The fact that antibiotics may be rapidly removed from the blood during hemoperfusion should be considered in calculation of the therapeutic dose of antibiotic required for patients who receive this procedure. Also, hemoperfusion can effectively and rapidly remove certain antibiotics from the blood of patients who have had a potentially toxic overdose.

This publication has 0 references indexed in Scilit: