Osteosarcoma associated with osteopoikilosis.

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Abstract
A roentgenographic search for active osteogenesis was done within bone islands from 1972-1975, and only a minimum change in the size and shape of individual bone islands was found. Histological evidence of some osteoblastic activity in a bone island a few centimeters distant from the tumor and more activity in the bone island in direct cellular continuity with the osteosarcoma of the proximal part of the tibia supports the association between cellular activity in bone and malignant transformation. The incidence of osteopoikilosis was judged to be 1 in 50,000 while the incidence of osteosarcoma is 1 in 100,000. The occurrence of the 2 rare conditions in the same patient suggests more than a coincidental relationship between them. Primary osteosarcoma in a long bone of a 48 yr old man also is unusual. In this patient the 2 conditions were related. Perhaps the chronic abnormal remodeling of bone involving bone islands in the lines of stress predisposed those lesions to malignant transformation.

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