VARIATIONS IN THE PERMEABILITY OF THE RED BLOOD CELLS IN MAN, WITH PARTICULAR REFERENCE TO THE CONDITIONS OBTAINING IN PERNICIOUS ANEMIA
Open Access
- 1 May 1937
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 16 (3) , 279-288
- https://doi.org/10.1172/jci100857
Abstract
The eryth-rocyte permeability to glucose presented slight individual variations in 12 normal subjects. In 9 patients with posthemorrhagic anemia and 20 patients with miscellaneous diseases somewhat more pronounced variations were found. 4 cases of untreated pernicious anemia gave distinctly raised permeability readings (up to 4 times the normal avg. value) and the same was found in 4 out of 6 cases receiving treatment. During specific treatment the permeability became normal in all 7 cases examined, in some instances within the first 1-3 days of treatment. The permeability to malonamid and thio-urea paralleled the glucose permeability.Keywords
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