830‐nm irradiation increases the wound tensile strength in a diabetic murine model*

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Abstract
Background and Objective The purpose of this study was to investigate the effects of low‐power laser irradiation on wound healing in genetic diabetes. Study Design/Materials and Methods Female C57BL/Ksj/db/db mice received 2 dorsal 1 cm full‐thickness incisions and laser irradiation (830 nm, 79 mW/cm2, 5.0 J/cm2/wound). Daily low‐level laser therapy (LLLT) occurred over 0–4 days, 3–7 days, or nonirradiated. On sacrifice at 11 or 23 days, wounds were excised, and tensile strengths were measured and standardized. Results Nontreated diabetic wound tensile strength was 0.77 ± 0.22 g/mm2 and 1.51 ± 0.13 g/mm2 at 11 and 23 days. After LLLT, over 0–4 days tensile strength was 1.15 ± 0.14 g/mm2 and 2.45 ± 0.29 g/mm2 (P = 0.0019). Higher tensile strength at 23 days occurred in the 3‐ to 7‐day group (2.72 ± 0.56 g/mm2 LLLT vs. 1.51 ± 0.13 g/mm2 nontreated; P ≤ 0.01). Conclusion Low‐power laser irradiation at 830 nm significantly enhances cutaneous wound tensile strength in a murine diabetic model. Further investigation of the mechanism of LLLT in primary wound healing is warranted. Lasers Surg. Med. 28:220–226, 2001.

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