Diphenylhydantoin and Diazepam: Molecular Structure Similarities and Steric Basis of Anticonvulsant Activity

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Abstract
Diphenylhydantoin and diazepam are two useful antiepileptic drugs. Though not obviously related chemically, their molecular conformations exhibit marked similarities. These similarities indicate a steric basis for their anticonvulsant activity and lead to conclusions about the receptor sites for this type of pharmaceutical.