Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection
Open Access
- 7 June 2007
- journal article
- Published by Springer Nature in Virology Journal
- Vol. 4 (1) , 55
- https://doi.org/10.1186/1743-422x-4-55
Abstract
Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in different cells. The COX inhibitors reduced MHV infection at a post-binding step, but early in the replication cycle. Both viral RNA and viral protein synthesis were affected with subsequent loss of progeny virus production. Thus, COX activity appears to be required for efficient MHV replication, providing a potential target for anti-coronaviral therapy.Keywords
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