Regulation of Immune Responses in Lymphatic Filariasis
- 28 September 2007
- book chapter
- Published by Wiley
- Vol. 127, 164-179
- https://doi.org/10.1002/9780470513446.ch11
Abstract
The nature and intensity of immune reactions to filarial antigens appear to be controlled by two broad mechanisms: immunoregulation and immune tolerance. Parasite molecules of high molecular weight activate suppressor T lymphocytes; suppressive parasite products are present in sera from microfilaraemic patients. Prenatal or perinatal exposure to soluble parasite antigens may influence a person's future ability to react to filarial antigens.Keywords
This publication has 24 references indexed in Scilit:
- Reduced lymphocyte response to mitogens in patients with Bancroftian filariasisTransactions of the Royal Society of Tropical Medicine and Hygiene, 1986
- Development of Brugia pahangi infections and lymphatic lesions in male offspring of female jirds with homologous infectionsTransactions of the Royal Society of Tropical Medicine and Hygiene, 1986
- Parasite antigen-specific human T cell lines and clones. Major histocompatibility complex restriction and B cell helper function.Journal of Clinical Investigation, 1984
- Immunological aspects of lymphatic filariasis and onchocerciasis in manTransactions of the Royal Society of Tropical Medicine and Hygiene, 1984
- Prenatal allergic sensitization to helminth antigens in offspring of parasite-infected mothers.Journal of Clinical Investigation, 1983
- Antigen-Specific Suppressor T Lymphocytes in Human Lymphatic FilariasisNew England Journal of Medicine, 1982
- Immunopathology of lymphatic filariasis in manSpringer Seminars in Immunopathology, 1980
- Evidence for increased susceptibility of Brugia pahangi-infected jirds (Meriones unguiculatus) to subsequent homologous infectionsJournal of Helminthology, 1980
- Antigen-Specific Suppressor Cells and Suppressor Factors in Human Filariasis withBrugia malayiNew England Journal of Medicine, 1980
- Immune responses in human infections with Brugia malayi: specific cellular unresponsiveness to filarial antigens.Journal of Clinical Investigation, 1980