Application of Supercritical Fluid Extraction to Components of Crude Drugs and Plants. I. Effects of Pressure, Temperature, Time and Entrainers on Supercritical Fluid Extraction of Cnidium formosanum YABE Fruits
Open Access
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 107 (5) , 367-371
- https://doi.org/10.1248/yakushi1947.107.5_367
Abstract
The supercritical fluid extraction was applied to the components of Cnidium formosanum fruits by use of carbon dioxide gas, and the effects of temperature, pressure and time on the extraction were examined to establish the way of applying this new technique to crude drugs. The optimum temperature and pressure for the extraction of furocoumarins such as columbianadin, bergapten, O-acetylcolubianetin, edultin and columbianetin, with supercritial carbon dioxide were 40.degree.C and 400 bar, respectively. Although the amounts of extractives increased with prolonging extraction times, the increments after 80 min were small. Effects of entrainers were examined, and compared with those of the ordinary liquid extraction.Keywords
This publication has 0 references indexed in Scilit: