Chenodeoxycholic Acid: The Mayo Clinic Experience

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Abstract
When clinical studies of potential gallstone-dissolving agents began, it was thought that all the natural bile components might be suitable and that the goal of pharmacologic dissolution might be achieved through expansion of the bile acid pool. But the experience described here showed that only chenodeoxycholic acid dissolved stones, that it dissolved only cholesterol gallstones, and that it acts by rendering bile unsaturated in cholesterol.