Nitric Oxide/cGMP Mediates the Spasmolytic Action of 3,4′-Dihydroxy-5,5′-dimethoxybibenzyl fromScaphyglottis livida

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Abstract
Five aromatic compounds, 3,4′-dihydroxy-5,5′ -dimethoxybibenzyl (1), batatasin III (2), coelonin (3), 3,7-dihydroxy-2,4-dimethoxyphenanthrene (4), and 3,7-dihydroxy-2,4,8-trimethoxyphenanthrene (5) were isolated from the orchid Scaphyglottis livida (Lindley) Schltr. Compounds 1 -5 induced a concentration-dependent inhibition of the spontaneous contractions of the rat ileum with potencies comparable or higher to that of papaverine. The relaxation evoked by compounds 1-4 was blocked by L-NAME, an inhibitor of nitric oxide synthase. It was also demonstrated that 1 increased cyclic GMP content in rat ileum rings. Compound 1-induced elevation of cGMP was inhibited by L-NAME and ODQ, inhibitors of nitric oxide synthase and soluble guanylyl cyclase, respectively. These results indicate that nitric oxide/cGMP formation constitute the signaling pathway in the spasmolytic action of compound 1. 1 Chemical Studies on Mexican Plants Used in Traditional Medicine XXXIX. Taken in part from the PhD thesis of S. Estrada.

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