Effects of Saikosaponins on Liver Tyrosine Aminotransferase Activity induced by Cortisone in Adrenalectomized Rats

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Abstract
Liver tyrosine aminotransferase activity is known to be induced by administration of steroids to adrenalectomized rats. When saikosaponin a, b1, b2, b3, b4, c, d or f was injected intraperitoneally into adrenalectomized rats, no induction of liver tyrosine aminotransferase activity was observed. Administration of a low dose of cortisone (6.4 µmol/kg) to adrenalectomized rats also did not induce liver tyrosine aminotransferase. But this enzyme was induced on administration of this low dose of cortisone with saikosaponen a (6.4 or 12.8 µmol/kg), d (6.4 or 12.8 µmol/kg) or f (12.8 µmol/kg). The sturcture-activity relationship of the effects of various Saikosaponins on the action of cortisone is discuused.