PREVENTION OF REJECTION OF ALLOGENEIC BONE MARROW TRANSPLANTS BY NK 1.1 ANTISERUM

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Abstract
The effect of in vivo administration of NK 1.1 antiserum was studied on 2 functions of natural killer (NK) cells: in vitro cytotoxicity of B6 mice to mouse T cell lymphoma YAC-1 cells, and potential of B6 mice to reject allogeneic BALB/c bone marrow transplants. A single i.v. injection of 0.4 ml of NK 1.1 antiserum significantly reduced in vitro NK cell cytotoxic potential and concomitantly prevented rejection of allogeneic bone marrow transplants. NK 1.1 antiserum was effective in diminishing both of these functions when injected 2, 6 or 24 h before transplantation and NK cell assay, but it was ineffective when given 48 h before transplantation or the NK cell test. As a specificity control, the effect of specific anti-T-cell-directed monoclonal antibodies, Thy 1.2 and Lyt 2.2, in the same systems was investigated. Neither of these antibodies exerted any effect on NK cell cytotoxicity to YAC-1 or rejection of allogeneic bone marrow transplants. NK cells represent a major component of the mechanism of bone marrow graft rejection.

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