Regional Brain Metabolic Changes in Patients With Major Depression Treated With Either Paroxetine or Interpersonal Therapy

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Abstract
THE REGIONS most commonly found to be abnormal in functional brain imaging studies of major depressive disorder (MDD) are the prefrontal cortex (PFC), anterior cingulate gyrus (AC), and temporal lobe (TEMP).1-4 Because there are reports of both increased and decreased activity in these structures in MDD, researchers have suspected that subregions of these structures have differentially altered function in MDD. Specifically, it has been hypothesized that dorsal brain structures (eg, dorsolateral prefrontal cortex [DLPFC]) have decreased activity,1-3,5-7 while ventral structures (eg, ventrolateral prefrontal cortex [VLPFC] and ventral AC) have increased activity in the symptomatic depressed state.3,5,6,8