TOXIC HEPATITIS DUE TO SULFANILAMIDE

17 December 1938

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 111 (25) , 2283-2285
https://doi.org/10.1001/jama.1938.02790510031007

Abstract

Although numerous toxic effects of sulfanilamide have been described, there are only a few references in the literature to damage to the liver produced by this drug. Hageman and Blake¹have observed one case of toxic hepatitis presumably due to sulfanilamide. This patient recovered promptly when the drug was discontinued. Saphirstein²has recorded a severe but nonfatal case of toxic hepatitis caused by sulfanilamide. In this instance there was an associated exfoliative dermatitis. Two deaths from hepatitis following the use of sulfanilamide have been reported by Bannick, Brown and Foster.³They felt that possibly their patients suffered hepatic damage prior to the beginning of the treatment and concluded that sulfanilamide may cause preexisting hepatic damage to progress to a stage from which regeneration is impossible. In contrast to this complication they have seen mild attacks of jaundice, which usually subsided rapidly when use of the drug was

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