Association of Gag‐Specific T Lymphocyte Responses during the Early Phase of Human Immunodeficiency Virus Type 1 Infection and Lower Virus Load Set Point
- 15 October 2002
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 186 (8) , 1177-1180
- https://doi.org/10.1086/343811
Abstract
T lymphocyte responses to human immunodeficiency virus (HIV) type 1 Gag were measured in 9 patients by interferon-γ enzyme-linked immunospot assay at 3 time points within 12 months of infection. Patients with early recognition of HIV-1 Gag had lower subsequent HIV-1 load set points, as measured during the first 2 years of infection, compared with those of patients with undetectable Gag-specific responses (median, 4.27 vs. 5.05 log10 HIV-1 RNA copies/mL, respectively; P=.028). An inverse correlation existed between the magnitude of the Gag-specific responses and the HIV-1 load set point (r=-0.733; P=.025). Early sustained T lymphocyte responses to HIV-1 Gag may be important for the establishment of virus load set pointKeywords
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