Needle-Stick Transmission of Human Colonic Adenocarcinoma

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Abstract
To the Editor: Transplantation of allogeneic tissue from one human into another normally leads to a cell-mediated immune response that rejects the transplanted tissue.1 We report a case of accidental injection of a human colonic adenocarcinoma cell line across HLA disparities into an otherwise healthy laboratory worker, with the subsequent sustained growth of a tumor nodule.The patient was a healthy 19-year-old woman, employed in a laboratory outside the National Institutes of Health, who had no clinical history to suggest immune deficiency. While she was injecting mice, her left hand was accidentally punctured by a needle that had previously been . . .

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