DNA Binding Activity of theEscherichia coliNitric Oxide Sensor NorR Suggests a Conserved Target Sequence in Diverse Proteobacteria

Open Access
Publisher Website
Google Scholar
Abstract
TheEscherichia colinitric oxide sensor NorR was shown to bind to the promoter region of thenorVWtranscription unit, forming at least two distinct complexes detectable by gel retardation. Three binding sites for NorR and two integration host factor binding sites were identified in thenorR-norVintergenic region. The derived consensus sequence for NorR binding sites was used to search for novel members of theE. coliNorR regulon and to show that NorR binding sites are partially conserved in other members of the proteobacteria.